Rheumatology & Autoimmune

3+ hour, 1+ min ago   (76+ words) Every second of every day, billions of your cells quietly die. Far from being a catastrophe, this mass dying is part of the body’s routine housekeeping, and a specialized force of immune cells stands ready to devour the wreckage. Macrophages,…...

3+ hour, 41+ min ago   (778+ words) Why do genetic variants that raise the risk of autoimmune disease remain so common in the human population? Evolutionary logic would seem to argue that harmful versions of genes should slowly disappear, yet many of the inherited risk factors for…...

2+ day, 5+ hour ago   (146+ words) Adam Faye, MD, of NYU Langone Health, New York, New York, shares results from a study evaluating the safety of guselkumab among older populations of patients with immune-mediated inflammatory diseases, such as inflammatory bowel disease (IBD), psoriasis, and psoriatic arthritis....

3+ day, 9+ hour ago   (78+ words) TradingView IFRX: INF904 advances in ANCA vasculitis with phase II trials planned and strong regulatory engagement A strategic pivot prioritizes ANCA vasculitis with INF904, designed for better safety and efficacy, and vilobelimab as a bridging option amid competitor withdrawals. Regulatory engagement is…...

3+ day, 13+ hour ago   (12+ words) FirstWord Pharma...

3+ day, 16+ hour ago   (590+ words) Scientists at Cedars-Sinai have demonstrated that TY1, a synthetic non-coding RNA originally developed to address heart attack-related tissue damage, can reduce inflammation, DNA damage and organ scarring in preclinical models of systemic sclerosis. Researchers at Cedars-Sinai Health Sciences University have used…...

3+ day, 17+ hour ago   (440+ words) EMJ This site is intended for healthcare professionals Hepatitis C in Cryoglobulinemic Vasculitis: Autoimmune Outcomes - Hepatitis C-related cryoglobulinemic vasculitis confers better event-free survival than autoimmune causes. - Low C4 complement and rheumatoid factor positivity independently predict poor event-free survival. - Underlying autoimmune etiology,…...

3+ day, 19+ hour ago   (81+ words) Beeline Medicines reports promising mid-stage lupus data Endpoints News Bee­line Med­i­cines re­ports promis­ing mid-stage lu­pus da­ta The busi­ness of ad­vanc­ing shelved phar­ma as­sets con­tin­ues to reap…...

4+ day, 1+ hour ago   (273+ words) Investigators reviewed observational studies evaluating the association between APOL1 risk variants and renal outcomes in patients with SLE. The analysis included four studies comprising 1,885 patients of African ancestry, including 321 individuals with high-risk APOL1 genotypes and 1,564 with low-risk variants. Across the pooled dataset,…...

4+ day, 14+ hour ago   (289+ words) Some people with chronic cutaneous lupus erythematosus may be less likely to acquire life-threatening infections when taking the drug anifrolumab (Saphnelo, AstraZeneca). Published in the Journal of the European Academy of Dermatology and Venereology (JEADV), the findings highlight how anifrolumab…...